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Effect of Polystyrene Nanoplastics and Their Degraded Forms on Stem Cell Fate by Gwang-Bum Im; Young Geon Kim; In-Seong Jo; Tae Yong Yoo; Sung-Won Kim; Hyun Su Park; Taeghwan Hyeon; Gi-Ra Yi; Suk Ho Bhang is a Environmental Science article available to read on EtoBox.

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Several studies have examined the effects of micro- and nanoplastics on microbes, cells, and the environment. However, only a few studies have examined their effects-especially, those of their reduced cohesiveness-on cell viability and physiology. We synthesized surfactant-free amine-functionalized polystyrene (PS) nanoparticles (NPs) and PS-NPs with decreased crosslinking density (DPS-NPs) without changing other factors, such as size, shape, and zeta potential and examined their effects on cell viability and physiology. PS- and DPS-NPs exhibited reactive oxygen species (ROS) scavenging activity by upregulating GPX3 expression and downregulating HSP70 (ROS-related gene) and XBP1 (endoplasmic reticulum stress-related gene) expression in human bone marrow-derived mesenchymal stem cells (hBM-MSCs). Additionally, they led to upregulation of MFN2 (mitochondrial fusion related gene) expression and downregulation of FIS1 (mitochondrial fission related gene) expression, indicating enhanced mitochondrial fusion in hBM-MSCs. Cell-cycle analysis revealed that PS- and DPS-NPs increased the proportion of cells in the S phase, indicating that they promoted cell proliferation and, specifically, t

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Author

Gwang-Bum Im; Young Geon Kim; In-Seong Jo; Tae Yong Yoo; Sung-Won Kim; Hyun Su Park; Taeghwan Hyeon; Gi-Ra Yi; Suk Ho Bhang

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Environmental Science (Physical Sciences)