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Identifying Subtypes of Patients with Neovascular Age-related Macular Degeneration by Genotypic and Cardiovascular Risk Characteristics by Michael Feehan; John Hartman; Richard Durante; Margaux A Morrison; Joan W Miller; Ivana K Kim; Margaret M DeAngelis is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Identifying Subtypes of Patients with Neovascular Age-related Macular Degeneration by Genotypic and Cardiovascular Risk Characteristics about?
## Background One of the challenges in the interpretation of studies showing associations between environmental and genotypic data with disease outcomes such as neovascular age-related macular degeneration (AMD) is understanding the phenotypic heterogeneity within a patient population with regard to any risk factor associated with the condition. This is critical when considering the potential therapeutic response of patients to any drug developed to treat the condition. In the present study, we identify patient subtypes or clusters which could represent several different targets for treatment development, based on genetic pathways in AMD and cardiovascular pathology. ## Methods We identified a sample of patients with neovascular AMD, that in previous studies had been shown to be at elevated risk for the disease through environmental factors such as cigarette smoking and genetic variants including the complement factor H gene (__CFH__) on chromosome 1q25 and variants in the __ARMS2__/HtrA serine peptidase 1 (__HTRA1__) gene(s) on chromosome 10q26. We conducted a multivariate segmentation analysis of 253 of these patients utilizing available epidemiologic and genetic data. ## Results
Who reads Identifying Subtypes of Patients with Neovascular Age-related Macular Degeneration by Genotypic and Cardiovascular Risk Characteristics?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Michael Feehan; John Hartman; Richard Durante; Margaux A Morrison; Joan W Miller; Ivana K Kim; Margaret M DeAngelis
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC (ISSN 1471-2350)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)