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Mechanism on antigen delivery under mucosal vaccination using cell-penetrating peptides immobilized at multiple points on p ... 1 1 Introduction 1 2 Material and methods 2 2.1 Materials 2 2.2 Immunization of mice with antigens in the presence of either D-octaarginine-linked PNVA-co-AA or components 2 2.3 Antibody titration 3 2.4 Confocal imaging of nasal sections 3 2.5 Quantitative evaluation of cellular uptake of antigens mixed with either D-octaarginine-linked PNVA-co-AA or components 3 2.6 Interactions between F-OVA and either D-octaarginine-linked PNVA-co-AA or components 3 2.7 Size distribution 3 2.8 D-Octaarginine-linked PNVA-co-AA-induced uptake of F-OVA in DC2.4 cells in the presence of an excess amount of intact OVA 3 2.9 Statistical analysis 3 3 Results 3 3.1 Adjuvant activities of D-octaarginine-linked PNVA-co-AA and components 3 3.2 Retention of antigens on the mucosa in the presence of either D-octaarginine-linked PNVA-co-AA or components 4 3.3 Cellular uptake of antigens in the presence of either D-octaarginine-linked PNVA-co-AA or components 4 3.4 Interactions of F-OVA with either D-octaarginine-linked PNVA-co-AA or components 4 3.5 D-Octaarginine-linked PNVA-co-AA-i
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Common subject areas: history, science, philosophy, social sciences.
- Language
- EN
- Category
- nonfiction
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