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Low MGMT digital expression is associated with a better outcome of IDH1 wildtype glioblastomas treated with temozolomide by Isabella Gomes; Daniel Antunes Moreno; Mariana Bisarro dos Reis; Luciane Sussuchi da Silva; Letícia Ferro Leal; Gisele Melo Gonçalves; Caio Augusto Pereira; Marco Antônio Oliveira; Marcus de Medeiros Matsushita; Rui Manuel Reis is a Medicine article available to read on EtoBox.

What is Low MGMT digital expression is associated with a better outcome of IDH1 wildtype glioblastomas treated with temozolomide about?

## Introduction: Glioblastoma (gbm) is the deadliest primary brain tumor. the standard treatment consists of surgery, radiotherapy, and temozolomide (tmz). tmz response is heterogeneous, and mgmt promoter (mgmtp) methylation has been the major predictive biomarker. we aimed to describe the clinical and molecular data of gbms treated with tmz, compare mgmt methylation with mgmt expression, and further associate with patient's outcome. ## Methods: We evaluate 112 ffpe adult gbm cases. idh1 and atrx expression was analyzed by immunohistochemistry, hotspot tert promoter (tertp) mutations were evaluated by sanger or pyrosequencing, and mgmtp methylation was assessed by pyrosequencing and mgmt mrna expression using the ncounter® vantage 3dTM dna damage and repair panel. ## Results: Of the 112 gbms, 96 were idh1, and 16 were idh1. positive atrx expression was found in 91.6% (88/96) of idh and 43.7% (7/16) of idh. tertp mutations were detected in 70.4% (50/71) of idh. mgmtp methylation was found in 55.5% (35/63) of idh and 84.6% (11/13) of idh, and as expected, mgmtp methylation was significantly associated with a better response to tmz. mgmt expression was inversely correlated with mgmtp

Who reads Low MGMT digital expression is associated with a better outcome of IDH1 wildtype glioblastomas treated with temozolomide?

Author

Isabella Gomes; Daniel Antunes Moreno; Mariana Bisarro dos Reis; Luciane Sussuchi da Silva; Letícia Ferro Leal; Gisele Melo Gonçalves; Caio Augusto Pereira; Marco Antônio Oliveira; Marcus de Medeiros Matsushita; Rui Manuel Reis

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)