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This study investigates the local production of angiotensin II (Ang II) in the sensory dorsal root ganglia (DRG) of rats and humans, focusing on the expression of key components of the renin-angiotensin system. The findings reveal significant expression of angiotensinogen and angiotensin-converting enzyme mRNA in rat DRG, with evidence of Ang II presence and its colocalization with neuropeptides like Substance P and CGRP, suggesting a role in nociception regulation. Overall, the results indicate that Ang II

Author

Emanuel Peralta

Language

EN