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The use of X-ray microtomography to investigate the microstructure of pharmaceutical tablets: Potentials and comparison to common physical methods by Schomberg, Ann Kathrin (author);Diener, Alexander (author);Wünsch, Isabell (author);Finke, Jan Henrik (author);Kwade, Arno (author) is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is The use of X-ray microtomography to investigate the microstructure of pharmaceutical tablets: Potentials and comparison to common physical methods about?
Within this study, tablets microstructure was investigated by X-ray microtomgraphy. The aim was to gain information about their microstructure, and thus, derive deeper interpretation of tablet properties (mechanical strength, component distribution) and qualified property functions. Challenges in image processing are discussed for the correct identification of solids and voids. Furthermore, XMT measurements are critically compared with complementary physical methods for characterizing active pharmaceutical ingredient (API) content and porosity and its distribution (mercury porosimetry, calculated tablet porosity, Focused Ion Beam-Scanning Electron Microscopy (FIB-SEM)). The derived porosity by XMT is generally lower than the calculated porosity based on geometrical data due to the resolution of the XMT in relation to the pore sizes in tablets. With rising compactions stress and API concentration, deviations between the actual and the calculated API decrease. XMT showed that API clusters are present for all tablets containing >1 wt% of ibuprofen. The 3D orientation of the components is assessable by deriving cord lengths along all dimensions of the tablets. An increasing compaction
Who reads The use of X-ray microtomography to investigate the microstructure of pharmaceutical tablets: Potentials and comparison to common physical methods?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- Schomberg, Ann Kathrin (author);Diener, Alexander (author);Wünsch, Isabell (author);Finke, Jan Henrik (author);Kwade, Arno (author)
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)