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Long-term Trial of Cyproheptadine as an Appetite Stimulant in Cystic Fibrosis by Douglas N. Homnick; John H. Marks; Karyl L. Hare; Sally K. Bonnema is a Medicine article available to read on EtoBox.

What is Long-term Trial of Cyproheptadine as an Appetite Stimulant in Cystic Fibrosis about?

Appetite stimulants have been used to help overcome decreased appetite and malnutrition in children and adults with various chronic illnesses, including cystic fibrosis (CF). Stimulants have included megestrol acetate (MA), cyproheptadine hydrochloride (CH), cannabinoids, hydrazine sulfate, anabolic hormones, and growth hormone. Many of these, including MA, have substantial side effects and may not be suitable for prolonged use. We previously studied the effects of CH on weight gain in a short-term (12 week) trial in CF with good results compared to placebo. Side effects were few, and weight gain was significant. In this study, we sought to determine the effects of CH over a longer term in order to assess its suitability for prolonged use. Sixteen CF children and adults enrolled in the original short-term study subsequently entered this study, and 12 completed the 9-month trial. All patients receiving placebo in the original short-term study received CH 4 mg up to four times a day in the long-term study continuation, and those receiving CH in the short-term study continued on the drug. No pill counts were done, and patients were queried at quarterly visits as to their CH use. Anthr

Who reads Long-term Trial of Cyproheptadine as an Appetite Stimulant in Cystic Fibrosis?

Author

Douglas N. Homnick; John H. Marks; Karyl L. Hare; Sally K. Bonnema

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)

Published

2005

Language

EN

Field

Medicine (Health Sciences)