Can I read Toward the development of a universal grading system for ovarian epithelial carcinoma : Testing of a proposed system in a series of 461 patients with uniform treatment and follow-up on EtoBox?

Toward the development of a universal grading system for ovarian epithelial carcinoma : Testing of a proposed system in a series of 461 patients with uniform treatment and follow-up by Yoshio Shimizu; Seiryu Kamoi; Satoshi Amada; Futoshi Akiyama; Steven G. Silverberg is a Medicine article available to read on EtoBox.

What is Toward the development of a universal grading system for ovarian epithelial carcinoma : Testing of a proposed system in a series of 461 patients with uniform treatment and follow-up about?

## Background: Most published series of ovarian carcinoma find a correlation between histologic grade and survival, but the grading system used commonly is not specified, and several different systems exist, some of which use different criteria for different histologic types. however, several studies have shown marked interobserver variability in distinguishing among the histologic types of ovarian carcinoma. the authors attempted to derive a universal grading system for all invasive ovarian carcinomas (ioc), based on the nottingham system for grading all types of mammary carcinoma. ## Methods: The authors studied 461 patients with ioc of different histologic types and clinicopathologic stages who were treated in a uniform manner between 1980 and 1994 with surgery and cisplatin-based chemotherapy. all slides were reviewed and the tumors graded as follows: architectural pattern (predominant): glandular = 1, papillary = 2, and solid = 3; nuclear pleomorphism: slight = 1, moderate = 2, and marked = 3; mitotic activity (mitotic figures per 10 high-power fields [1 hpf = 0.345 mm2]) in most active region: 0-9 = 1, 10-24 = 2, and > or = 25 = 3; grade 1 = total score (adding three values o

Who reads Toward the development of a universal grading system for ovarian epithelial carcinoma : Testing of a proposed system in a series of 461 patients with uniform treatment and follow-up?

Author

Yoshio Shimizu; Seiryu Kamoi; Satoshi Amada; Futoshi Akiyama; Steven G. Silverberg

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1998

Language

EN

Field

Medicine (Health Sciences)