Opening book details…
Can I read The Use of Molecular Genetic Markers to Demonstrate the Effect of Organ Environment on Clonal Dominance in a Human Renal-cell Carcinoma Grown in Nude Mice on EtoBox?
The Use of Molecular Genetic Markers to Demonstrate the Effect of Organ Environment on Clonal Dominance in a Human Renal-cell Carcinoma Grown in Nude Mice by Alexander N. Staroselsky; Robert Radinsky; Isaiah J. Fidler; Sen Pathak; Yuti Chernajovsky; Philip Frost is a Medicine article available to read on EtoBox.
What is The Use of Molecular Genetic Markers to Demonstrate the Effect of Organ Environment on Clonal Dominance in a Human Renal-cell Carcinoma Grown in Nude Mice about?
## Abstract Transduction of the SNI2C human renal‐cell carcinoma line with the __neo__^R^ gene produces a genetically „tagged”︁ cell population within which individual clones can be identified if they dominate the tumor during its growth __in vivo__. We used this technique to determine whether the clones that dominate the primary local tumor and its metastases are the same or different when the tumor is growing in different organ sites in nude mice. The results show that clonal dominance is influenced by the organ environment in which the primary tumor grows, __i.e.__, distinct clones dominated in the kidney, colon and subcutaneous sites. In addition, tumors grown in the orthotopic site (kidney) were all populated by the same dominant clones, and each distant visceral metastasis retained the same clonality. SNI2C __neo__^R^‐cells grown in an epithelial, ectopic site (colon) produced tumors with uniquely different dominant clones, and their visceral metastases retained the dominant pattern expressed by the parent tumor from which they were derived. In contrast, SNI2C tumors growing subcutaneously showed a random pattern of clonal dominance in both their primary and metastatic sites.
Who reads The Use of Molecular Genetic Markers to Demonstrate the Effect of Organ Environment on Clonal Dominance in a Human Renal-cell Carcinoma Grown in Nude Mice?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Alexander N. Staroselsky; Robert Radinsky; Isaiah J. Fidler; Sen Pathak; Yuti Chernajovsky; Philip Frost
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1992
- Language
- EN
- ISBN
- 9782910510121
- Field
- Medicine (Health Sciences)