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Mutations and environmental factors affecting regulation of riboflavin synthesis and iron assimilation also cause oxidative stress in the yeast Pichia guilliermondii by Yuriy R. Boretsky; Olga V. Protchenko; Tetiana M. Prokopiv; Igor O. Mukalov; Daria V. Fedorovych; Andriy A. Sibirny is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract Iron deficiency causes oversynthesis of riboflavin in several yeast species, known as flavinogenic yeasts. However, the mechanisms of such regulation are not known. We found that mutations causing riboflavin overproduction and iron hyperaccumulation (__rib80, rib81__ and __hit1__), as well as cobalt excess or iron deficiency all provoke oxidative stress in the __Pichia guilliermondii__ yeast. Iron content in the cells, production both of riboflavin and malondialdehyde by __P. guilliermondii__ wild type and __hit1__ mutant strains depend on a type of carbon source used in cultivation media. The data suggest that the regulation of riboflavin biosynthesis and iron assimilation in __P. guilliermondii__ are linked with cellular oxidative state. (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Who reads Mutations and environmental factors affecting regulation of riboflavin synthesis and iron assimilation also cause oxidative stress in the yeast Pichia guilliermondii?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yuriy R. Boretsky; Olga V. Protchenko; Tetiana M. Prokopiv; Igor O. Mukalov; Daria V. Fedorovych; Andriy A. Sibirny
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Akademie Verlag; Wiley (ISSN 0233-111X)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)