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Examination of Bcl‐2, Bcl‐X and bax protein expression in psoriasis by Mukadder Koçak; Önder Bozdoǧan; Emel Erkek; Pínar Atasoy; Ahu Birol is a Medicine article available to read on EtoBox.

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## Abstract **Background** Psoriasis is an inflammatory skin disease characterized by epidermal hyperplasia and greatly accelerated epidermal turnover. The blockage of normal apoptotic process in the epidermis is one of the factors implicated in the pathogenesis of psoriasis. **Objective** The purpose of the present study was to elucidate whether bcl‐family proteins are significantly involved in the hypothetical antiapoptotic cascade in lesional psoriatic epidermis. **Methods** Twenty‐six lesional biopsy samples of 26 patients with psoriasis and five control specimens from normal skin were studied by immunohistochemical method for the differential expression of pro‐apoptotic bax and antiapoptotic bcl‐2 and bcl‐x proteins. **Results** Compared with the normal epidermis, bcl‐2 expression was significantly reduced, whereas bax and bcl‐x were significantly overexpressed in the psoriatic epidermis. The localization of bcl‐2/bax/bcl‐x proteins in the psoriatic epidermis did not show a significant deviation from that in the normal epidermis. **Conclusion** These findings indicate a discordant expression of bcl‐2 and bax/bcl‐x in psoriatic epidermis. Increased bcl‐x expression might contri

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Author

Mukadder Koçak; Önder Bozdoǧan; Emel Erkek; Pínar Atasoy; Ahu Birol

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0011-9059)

Published

2003

Language

EN

Field

Medicine (Health Sciences)