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Can I read Caspase Inhibitors: a Review of Recently Patented Compounds (2013-2015) on EtoBox?
Caspase Inhibitors: a Review of Recently Patented Compounds (2013-2015) by Hyemin Lee; Eun Ah Shin; Jae Hee Lee; Deoksoo Ahn; Chang Geun Kim; Ju-Ha Kim; Sung-Hoon Kim is a Medicine article available to read on EtoBox.
What is Caspase Inhibitors: a Review of Recently Patented Compounds (2013-2015) about?
## Introduction: Although many caspase inhibitors have been patented, caspase inhibitors have not entered the market due to their toxicity and poor pharmacokinetic profile. ## Areas covered: In this article, we review patents (2013-2015) for peptide and non-peptide caspase inhibitors and their compositions. ## Expert opinion: Noteworthy patents include a peptidic caspase-2 inhibitor for nasal administration and a peptidomimetic caspase-6 inhibitor that can be administered via several routes for the treatment of neurodegenerative diseases. furthermore, caspase-1 inhibitors for contact dermatitis and inflammation, cardiovascular diseases, and liver diseases and a caspase-3 inhibitor for cerebral stroke have been patented. of particular interest is the novel use of tyrosine kinase inhibitors (sunitinib and its derivatives) for the prevention and treatment of age-related ocular diseases via inhibition of the caspase-3, dual-leucine zipper kinase (dlk) and leucine zipper-bearing kinase (lzk) pathways. however, for effective clinical application of caspase inhibitors, novel peptidic and nonpeptidic caspase inhibitors with lower toxicity and improved efficacy should be developed via struc
Who reads Caspase Inhibitors: a Review of Recently Patented Compounds (2013-2015)?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hyemin Lee; Eun Ah Shin; Jae Hee Lee; Deoksoo Ahn; Chang Geun Kim; Ju-Ha Kim; Sung-Hoon Kim
- Publisher
- Informa UK Limited
- Published
- 2017
- Language
- EN
- Field
- Medicine (Life Sciences)