Opening book details…
Can I read Heme oxygenase-1 (HO-1) protein induction in a mouse model of asthma on EtoBox?
Heme oxygenase-1 (HO-1) protein induction in a mouse model of asthma by O. Kitada; T. Kodama; K. Kuribayashi; D. Ihaku; M. Fujita; T. Matsuyama; M. Sugita is a Medicine article available to read on EtoBox.
What is Heme oxygenase-1 (HO-1) protein induction in a mouse model of asthma about?
**Background and objective** Carbon monoxide (CO) is known to be present in measurable quantities in the exhalation of asthmatic patients. Corticosteroid treatment resulted in a decrease in exhaled CO levels in asthmatic patients, raising the possibility that an increase in exhaled CO concentration reflects inflammation of the asthmatic airway. Heme oxygenase‐1 (HO‐1) protein, also called HSP32, is the rate‐limiting enzyme in the catabolism of heme to biliverdin, free iron and CO. However, it is unknown whether an expression of HO‐1 within the lung tissue is related to allergic airway inflammation. We studied the expression of HO‐1 in lung tissue and bronchoalveolar lavage cells in a mouse model of asthma. **Methods** Ovalbumin (OVA)‐sensitized C57BL/6 mice were challenged with aerosolized OVA. HO‐1 positive cells were identified by immunostaining in lung tissue and bronchoalveolar lavage fluid (BALF) after the challenge. **Results** HO‐1 positive cell numbers increased in the subepithelium of the bronchi after OVA challenge. In cytospin preparations from BALF after OVA challenge, HO‐1 was localized to alveolar macrophages. Inside the macrophages, HO‐1 reactivity was expressed in t
Who reads Heme oxygenase-1 (HO-1) protein induction in a mouse model of asthma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- O. Kitada; T. Kodama; K. Kuribayashi; D. Ihaku; M. Fujita; T. Matsuyama; M. Sugita
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0954-7894)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)