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This research paper investigates the pharmacokinetics of tramadol hydrochloride and its active metabolite, O-desmethyltramadol (M1), in male and female B6 mice after administration through various routes. The study found that high plasma concentrations of tramadol and M1 were achieved, with short half-lives varying by administration method, and that tramadol solutions remained stable for one week. The findings suggest tramadol may be a viable analgesic option for laboratory mice, addressing gaps in existing

Author

Juvanca Reva

Language

EN