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Can I read Finding the Dose for Ceftolozane-Tazobactam in Critically Ill Children with and without Acute Kidney Injury on EtoBox?
Finding the Dose for Ceftolozane-Tazobactam in Critically Ill Children with and without Acute Kidney Injury by Butragueño-Laiseca, Laura; Troconiz, Iñaki F.; Grau, Santiago; Campillo, Nuria; García, Xandra; Padilla, Belén; Fernández, Sarah N.; Santiago, María José is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Finding the Dose for Ceftolozane-Tazobactam in Critically Ill Children with and without Acute Kidney Injury about?
Background: Ceftolozane-tazobactam is a new antibiotic against multidrug-resistant pathogens such as Pseudomonas aeruginosas. Ceftolozane-tazobactam dosage is still uncertain in children, especially in those with renal impairment or undergoing continuous renal replacement therapy (CRRT). Methods: Evaluation of different ceftolozane-tazobactam dosing regimens in three critically ill children. Ceftolozane pharmacokinetics (PK) were characterized by obtaining the patient’s specific parameters by Bayesian estimation based on a population PK model. The clearance (CL) in patient C undergoing CRRT was estimated using the prefilter, postfilter, and ultrafiltrate concentrations simultaneously. Variables such as blood, dialysate, replacement, and ultrafiltrate flow rates, and hematocrit were integrated in the model. All PK analyses were performed using NONMEM v.7.4. Results: Patient A (8 months of age, 8.7 kg) with normal renal function received 40 mg/kg every 6 h: renal clearance (CLR) was 0.88 L/h; volume of distribution (Vd) Vd1 = 3.45 L, Vd2 = 0.942 L; terminal halflife (t1/2,β) = 3.51 h, dosing interval area under the drug concentration vs. time curve at steady-state (AUCτ,SS) 397.73 mg
Who reads Finding the Dose for Ceftolozane-Tazobactam in Critically Ill Children with and without Acute Kidney Injury?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Butragueño-Laiseca, Laura; Troconiz, Iñaki F.; Grau, Santiago; Campillo, Nuria; García, Xandra; Padilla, Belén; Fernández, Sarah N.; Santiago, María José
- Publisher
- MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI AG, 2012- (ISSN 2079-6382)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)