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Optic nerve regenerates but does not restore topographic projections in the lizardCtenophorus ornatus by Beazley, L.D.; Sheard, P.W.; Tennant, M.; Starac, D.; Dunlop, S.A. is a Neuroscience article available to read on EtoBox.
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In adult fish and amphibians, the severed optic nerve regenerates and visual behaviour is restored. By contrast, optic axons do not regenerate in the more recently evolved birds and mammals. Here we have investigated optic nerve regeneration in a member of the class Reptilia, phylogenetically intermediate between the fish and amphibians and the birds and mammals. We assessed visual recovery anatomically and behaviourally one year after unilateral optic nerve crush in the adult ornate dragon lizard, Ctenophorus ornatus. Ganglion cell densities and numbers of axons in the optic nerve on either side of the crush site indicated that two-thirds of ganglion cells survived axotomy and regrew their axons. However, myelination fell from a mean of 21% in normals to 5.5% and 3%, proximal and distal to the crush, respectively. Anterograde labelling of the entire optic nerve showed that axons regenerated along essentially normal pathways and that the major projection, as in normals, was to the superficial one-third of the contralateral optic tectum. However, localised retinal injections indicated that regenerated projections lacked retinotopic order. Any one retinal region projected to the enti
Who reads Optic nerve regenerates but does not restore topographic projections in the lizardCtenophorus ornatus?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Beazley, L.D.; Sheard, P.W.; Tennant, M.; Starac, D.; Dunlop, S.A.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)
- Published
- 1997
- Language
- EN
- Field
- Neuroscience (Life Sciences)
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