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Synthesis and Antimicrobial Activity of New Tetrahydro-naphthalene-thiazolidinedione and Thiohydantoine Derivatives by Zeynep Ates-Alagoz; Nurten Altanlar; Erdem Buyukbingol is a Chemistry article available to read on EtoBox.

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## Abstract magnified image As part of an ongoing program aimed at recognizing novel antioxidant, antimicrobial, and anticancer molecules, herein we report the synthesis and biological evaluation of imidazolidin‐4‐one and thiazolidine‐2,4‐dione derivatives as antimicrobial agents. These compounds were prepared from 5,5,8,8‐tetramethyl‐5,6,7,8‐tetrahydro‐naphthalen‐2‐carboxaldehyde and 3‐substituted phenacyl‐2,4‐thiazolidinediones using Knoevenagel reaction. The structures of compounds were confirmed by ^1^H NMR, mass spectral data, and elemental analyses. The molecules were evaluated for __in vitro__ antimicrobial activity against methicillin‐resistant __Staphylococcus aureus__ (MRSA) (standard), methicillin‐resistant __Staphylococcus aureus__ (isolated), __Staphylococcus aureus__ (SA), __Escherichia coli__ (EC), __Bacillus subtilis__ (BS), and __Candida albicans__ (CA). Compounds **3a**, **3b**, **3c**, **3d**, **3e**, **3f**, **3g** and compound **4** showed equal and/or greater antimicrobial activity against MRSA and EC than ampicillin and sultamicillin. J. Heterocyclic Chem., (2009)

Who reads Synthesis and Antimicrobial Activity of New Tetrahydro-naphthalene-thiazolidinedione and Thiohydantoine Derivatives?

Author

Zeynep Ates-Alagoz; Nurten Altanlar; Erdem Buyukbingol

Publisher

Journal of Heterocyclic Chemistry; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; FASEB (ISSN 0022-152X)

Published

2009

Language

EN

Field

Chemistry (Physical Sciences)