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Can I read Myogenic Progenitors Contribute to Open but Not Closed Fracture Repair on EtoBox?
Myogenic Progenitors Contribute to Open but Not Closed Fracture Repair by Renjing Liu; Oliver Birke; Alyson Morse; Lauren Peacock; Kathy Mikulec; David G Little; Aaron Schindeler is a Medicine article available to read on EtoBox.
What is Myogenic Progenitors Contribute to Open but Not Closed Fracture Repair about?
## Background Bone repair is dependent on the presence of osteocompetent progenitors that are able to differentiate and generate new bone. Muscle is found in close association with orthopaedic injury, however its capacity to make a cellular contribution to bone repair remains ambiguous. We hypothesized that myogenic cells of the MyoD-lineage are able to contribute to bone repair. ## Methods We employed a __MyoD__-Cre^+^:Z/AP^+^ conditional reporter mouse in which all cells of the MyoD-lineage are permanently labeled with a __human alkaline phosphatase (hAP)__ reporter. We tracked the contribution of MyoD-lineage cells in mouse models of tibial bone healing. ## Results In the absence of musculoskeletal trauma, MyoD-expressing cells are limited to skeletal muscle and the presence of reporter-positive cells in non-muscle tissues is negligible. In a closed tibial fracture model, there was no significant contribution of hAP^+^ cells to the healing callus. In contrast, open tibial fractures featuring periosteal stripping and muscle fenestration had up to 50% of hAP^+^ cells detected in the open fracture callus. At early stages of repair, many hAP^+^ cells exhibited a chondrocyte morpholo
Who reads Myogenic Progenitors Contribute to Open but Not Closed Fracture Repair?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Renjing Liu; Oliver Birke; Alyson Morse; Lauren Peacock; Kathy Mikulec; David G Little; Aaron Schindeler
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2474)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)