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8659 Interleukin-33 Promotes Endometriosis Fibrosis by Inducing Fibroblast to Myofibroblast Transformation. by J. Ruan; Q. Tian; Y. Wang; K. Chang; X. Yi is a Medicine article available to read on EtoBox.

What is 8659 Interleukin-33 Promotes Endometriosis Fibrosis by Inducing Fibroblast to Myofibroblast Transformation. about?

Study Objective Fibrosis is one of the important features of endometriosis (EMs). Inflammatory factors including interleukin (IL)- 33 enriched- microenvironment is implicated in the pathogenesis of fibrosis. However, the mechanism of IL-33 in fibrosis of EMs remains unclear. In this study, we elucidate the role of IL-33 in the regulation of fibrosis. Design N/A. Setting N/A. Patients or Participants N/A. Interventions Masson staining was performed to evaluate the degree of fibrosis. We examined the expression of lipid peroxides by immunofluorescence and the expression of IL-33 in the peritoneal fluid by ELISA. Eutopic and ectopic endometrial stromal cells (ESC) were cultured, and an oxidative stress model in vitro was established. The expression of IL-33 in the supernatant of ESC was detected by real-time PCR and ELISA under the oxidative stress model. Real-time PCR and western blotting were performed to evaluate the effect of IL-33 on fibroblast- myofibroblast transformation (FMT) of ESC. Measurements and Main Results The percentage of collagen area in ectopic endometriotic lesions was higher than in eutopic endometrium. The expression of IL33 in the peritoneal fluid was significa

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Author

J. Ruan; Q. Tian; Y. Wang; K. Chang; X. Yi

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)