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Efficacy of Laser Therapy Combined with Topical Antifungal Agents for Onychomycosis: a Systematic Review and Meta-analysis of Randomised Controlled Trials by Jianfeng Zhang; Peng Lin; Junchen Li; Chenqi Guo; Jingbo Zhai; Yu Zhang is a Medicine article available to read on EtoBox.

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## Introduction: Onychomycosis is a common fungal infection of the nail. laser and topical antifungal agent combination therapy is an emerging treatment for onychomycosis. the objective of this study was to systematically evaluate the efficacy and safety of laser and topical antifungal agent combination therapy for onychomycosis. ## Methods: The pubmed, embase, cochrane library, china national knowledge infrastructure, wanfang and vip databases were searched from inception to november 2021. randomised controlled trials (rcts) on laser therapy combined with topical antifungal agents for onychomycosis were included. the cochrane collaboration tool was used to assess the risk of bias, and revman 5.3 software was used in the meta-analysis. ## Results: Twelve studies involving 869 patients were included in this meta-analysis. the results showed that compared with topical antifungal agents alone, laser and topical antifungal agent combination therapy was superior in terms of the complete cure rate (rr 6.04,95% ci (2.17, 16.85), p = 0.0006), mycological cure rate (rr 1.27, 95% ci (1.10, 1.48), p = 0.001), clinical effective rate (rr 1.38, 95% ci (1.20, 1.57), p < 0.00001) and patient sati

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Author

Jianfeng Zhang; Peng Lin; Junchen Li; Chenqi Guo; Jingbo Zhai; Yu Zhang

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)