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Physicochemical and Biological Characterization of Functionalized Calcium Carbonate by Saara V. Sirkiä; Syeda Qudsia; Minna Siekkinen; Wolfgang Hoepfl; Tanja Budde; Jan-Henrik Smått; Jouko Peltonen; Leena Hupa; Terhi J. Heino; Pekka K. Vallittu is a Engineering article available to read on EtoBox.
What is Physicochemical and Biological Characterization of Functionalized Calcium Carbonate about?
Biocompatible and osteoconductive calcium carbonate (CC) and hydroxyapatite (HAP) have been studied as bone filling materials. In contrast to HAP, CC is highly resorbable, and to achieve optimal resorption rates, a functionalized calcium carbonate (FCC) consisting of CC particles with a HAP layer has been further developed. The aim of this study was to characterize the physicochemical and biological properties of FCC. Physicochemical properties were studied with ATR-FTIR, XRD and SEM. pH change and ion release were studied in a static system in cell culture medium or water, and in a continuous dynamic system in Tris-buffer. Viability and morphology of pre-osteoblastic cells in vitro was studied with a WST method, as well as with SEM and TEM imaging. There was a minor increase in pH in Tris-buffer and water dissolution systems at the beginning of FCC dissolution. In contrast, pH of the cell culture medium remained approximately unchanged during the dissolution. In Tris-buffer and water dissolution systems, increased levels of calcium release from FCC were detected, whereas in the cell culture medium FCC was shown to adsorb calcium from the medium, thus causing a decrease in the diss
Who reads Physicochemical and Biological Characterization of Functionalized Calcium Carbonate?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Saara V. Sirkiä; Syeda Qudsia; Minna Siekkinen; Wolfgang Hoepfl; Tanja Budde; Jan-Henrik Smått; Jouko Peltonen; Leena Hupa; Terhi J. Heino; Pekka K. Vallittu
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Engineering (Physical Sciences)