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Comparing a Novel Neuroanimation Experience to Conventional Therapy for High-Dose Intensive Upper-Limb Training in Subacute Stroke: The SMARTS2 Randomized Trial by John W. Krakauer; Tomoko Kitago; Jeff Goldsmith; Omar Ahmad; Promit Roy; Joel Stein; Lauri Bishop; Kelly Casey; Belen Valladares; Michelle D. Harran; Juan Camilo Cortés; Alexander Forrence; Jing Xu; Sandra DeLuzio; Jeremia P. Held; Anne Schwarz; Levke Steiner; Mario Widmer; Kelly Jordan; Daniel Ludwig; Meghan Moore; Marlena Barbera; Isha Vora; Rachel Stockley; Pablo Celnik; Steven Zeiler; Meret Branscheidt; Gert Kwakkel; Andreas R. Luft is a Medicine article available to read on EtoBox.
What is Comparing a Novel Neuroanimation Experience to Conventional Therapy for High-Dose Intensive Upper-Limb Training in Subacute Stroke: The SMARTS2 Randomized Trial about?
Background. Evidence from animal studies suggests that greater reductions in poststroke motor impairment can be attained with significantly higher doses and intensities of therapy focused on movement quality. These studies also indicate a dose-timing interaction, with more pronounced effects if high-intensity therapy is delivered in the acute/subacute, rather than chronic, poststroke period. Objective. To compare 2 approaches of delivering high-intensity, high-dose upper-limb therapy in patients with subacute stroke: a novel exploratory neuroanimation therapy (NAT) and modified conventional occupational therapy (COT). Methods. A total of 24 patients were randomized to NAT or COT and underwent 30 sessions of 60 minutes time-on-task in addition to standard care. The primary outcome was the Fugl-Meyer Upper Extremity motor score (FM-UE). Secondary outcomes included Action Research Arm Test (ARAT), grip strength, Stroke Impact Scale hand domain, and upper-limb kinematics. Outcomes were assessed at baseline, and days 3, 90, and 180 posttraining. Both groups were compared to a matched historical cohort (HC), which received only 30 minutes of upper-limb therapy per day. Results. There wer
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- Author
- John W. Krakauer; Tomoko Kitago; Jeff Goldsmith; Omar Ahmad; Promit Roy; Joel Stein; Lauri Bishop; Kelly Casey; Belen Valladares; Michelle D. Harran; Juan Camilo Cortés; Alexander Forrence; Jing Xu; Sandra DeLuzio; Jeremia P. Held; Anne Schwarz; Levke Steiner; Mario Widmer; Kelly Jordan; Daniel Ludwig; Meghan Moore; Marlena Barbera; Isha Vora; Rachel Stockley; Pablo Celnik; Steven Zeiler; Meret Branscheidt; Gert Kwakkel; Andreas R. Luft
- Publisher
- SAGE Publications
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)