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The study investigates the role of Starch Binding Domain-containing Protein 1 (Stbd1) in glycogen transport to lysosomes, particularly in the context of Pompe disease. It finds that Stbd1 is crucial for glycogen transport in the liver but not in skeletal muscle or heart, with significant reductions in lysosomal glycogen levels observed in Stbd1 knock-out mice. The research suggests that the N-terminal transmembrane region and the C-terminal carbohydrate binding module of Stbd1 are critical for its function
- Author
- Haiqing Yi
- Language
- EN