Can I read Can We Overcome the ‘Clinico-radiological Paradox’ in Multiple Sclerosis? on EtoBox?

Can We Overcome the ‘Clinico-radiological Paradox’ in Multiple Sclerosis? by Kerstin Hackmack; Martin Weygandt; Jens Wuerfel; Caspar F. Pfueller; Judith Bellmann-Strobl; Friedemann Paul; John-Dylan Haynes is a Medicine article available to read on EtoBox.

What is Can We Overcome the ‘Clinico-radiological Paradox’ in Multiple Sclerosis? about?

The association between common neuroradiological markers of multiple sclerosis (MS) and clinical disability is weak, a phenomenon known as the clinicoradiological paradox. Here, we investigated to which degree it is possible to predict individual disease profiles from conventional magnetic resonance imaging (MRI) using multivariate analysis algorithms. Specifically, we conducted cross-validated canonical correlation analyses to investigate the predictive information contained in conventional MRI data of 40 MS patients for the following clinical parameters: disease duration, motor disability (9-Hole Peg Test, Timed 25-Foot Walk Test), cognitive dysfunction (Paced Auditory Serial Addition Test), and the expanded disability status scale (EDSS). It turned out that the information in the spatial patterning of MRI data predicted the clinical scores with correlations of up to 0.80 (p \ 10 -9 ). Maximal predictive information for disease duration was identified in the precuneus and somatosensory cortex. Areas in the precuneus and precentral gyrus were maximally informative for motor disability. Cognitive dysfunction could best be predicted using data from the angular gyrus and superior par

Who reads Can We Overcome the ‘Clinico-radiological Paradox’ in Multiple Sclerosis??

Author

Kerstin Hackmack; Martin Weygandt; Jens Wuerfel; Caspar F. Pfueller; Judith Bellmann-Strobl; Friedemann Paul; John-Dylan Haynes

Publisher

Springer Science and Business Media LLC

Published

2012

Language

EN

Field

Medicine (Health Sciences)