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Can I read Epstein-Barr virus infection and P53 expression in HIV-related oral large B cell lymphoma on EtoBox?
Epstein-Barr virus infection and P53 expression in HIV-related oral large B cell lymphoma by Anna Calzolari; Alessandra Papucci; Gianna Baroni; Giuseppe Ficarra; Berardino Porfirio; Ilaria Chiarelli; Simonetta Di Lollo is a Medicine article available to read on EtoBox.
What is Epstein-Barr virus infection and P53 expression in HIV-related oral large B cell lymphoma about?
Background. Head and neck non-Hodgkin's lymphomas in HIV positive patients are highly related with Epstein-Barr virus (EBV) infection. In general, viral agents can alter p53 protein levels by enhancing degradation of cellular p53 or by increasing its half-life by viral protein-p53 interaction. Moreover, it has been reported that modifications of p53 gene can modulate tumor cells' response to radio-and chemotherapy. Methods. To assess a possible role of EBV infection, p53 protein deregulation, and p53 gene alterations in exons 5 to 8, we have studied six cases of HIV-related primary oral large B-cell lymphoma. We used in situ hybridization (ISH) for EBV-DNA and EBV-encoded nuclear RNA-1 (EBER-1), immunohistochemistry (IHC) for EBV latent membrane protein -1 (LMP-1) and p53 proteins expression, and single strand conformational polymorphism (SSCP) analysis to screen p53 gene mutations in exons 5 to 8. Results. The EBV-DNA was present in all specimens, according to conventional DNA-ISH. No evidence for EBER-1 was found by ISH. The presence of EBV-DNA was correlated with the LMP-1 expression in all but one case. Moreover, p53 protein expression was negative in three cases and strongly p
Who reads Epstein-Barr virus infection and P53 expression in HIV-related oral large B cell lymphoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Anna Calzolari; Alessandra Papucci; Gianna Baroni; Giuseppe Ficarra; Berardino Porfirio; Ilaria Chiarelli; Simonetta Di Lollo
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1043-3074)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)