Can I read Natural PPARs agonists for the treatment of nonalcoholic fatty liver disease on EtoBox?
Natural PPARs agonists for the treatment of nonalcoholic fatty liver disease by Jiashu Pan; Wenjun Zhou; Ruohui Xu; Lianjun Xing; Guang Ji; Yanqi Dang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Natural PPARs agonists for the treatment of nonalcoholic fatty liver disease about?
Nonalcoholic fatty liver disease (NAFLD) is a general term for a series of liver diseases including simple steatosis, non-alcoholic steatohepatitis, liver fibrosis, which is closely related to metabolic syndrome. The pathogenesis of NAFLD is relatively complex, which has gradually changed from the previous 'two-hit' hypothesis to the current "multiple hits" hypothesis. However, there is currently no approved treatment for NAFLD in clinic, highlighting the urgent need for drug development. Peroxisome proliferator activated receptors (PPARs) are members of the nuclear receptor superfamily, whose different subtypes have been proved to regulate different stages of NAFLD, thus becoming promising drug targets for NAFLD. As important sources of drug development, natural products have been proven to treat NAFLD through multiple pathways and multiple targets. In this paper, we outline the regulatory role of PPARs in NAFLD, and summarize some natural products that target PPARs to ameliorate NAFLD, in order to provide reference for drug development of NAFLD.
Who reads Natural PPARs agonists for the treatment of nonalcoholic fatty liver disease?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jiashu Pan; Wenjun Zhou; Ruohui Xu; Lianjun Xing; Guang Ji; Yanqi Dang
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)