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Proposal of a New Design of Source Heat Exchanger for the Technical Feasibility of Solar Thermal Plants Coupled to Supercritical Power Cycles by Montes, María José; Linares, José Ignacio; Barbero, Rubén; Rovira, Antonio is a Energy article available to read on EtoBox.

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Immunohistochemistry (IHC) was performed on tissue samples of untreated (n1⁄440) and chemotherapypretreated (n1⁄414) MPM patients. Different subsets if immune cells were identified based on staining for CD4, CD8, FoxP3, CD68, CD45RO and granzyme B. The expression of the immune checkpoints TIM-3, LAG-3, PD-1 and its ligand PD-L1 was also investigated. The relationship between the immunological parameters and survival, as well as response to chemotherapy was analyzed using the R statistical software. Results: All patients had CD8+ tumor infiltrating lymphocytes (TILs), CD68+ histiocytes and macrophages and CD45RO+ T cells in their stroma, with CD8+ TILs being the predominant cell type of the immune infiltrate. Stromal CD4+ TILs were found in 75% of the untreated and 71% of the pretreated samples. A subset of those cells was also FoxP3+ and these CD4+FoxP3+ cells were positively correlated with stromal CD4 expression (p<0.001). Less than half of the samples showed positivity for granzyme B. Both, untreated and pretreated patients had PD-1+ TILs, while only 10% of the untreated patients also had PD-1+ tumor cells. PD-L1 positivity on lymphocytes and/or tumor cells was observed for more

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Author

Montes, María José; Linares, José Ignacio; Barbero, Rubén; Rovira, Antonio

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0038-092X)

Published

2020

Language

EN

Field

Energy (Physical Sciences)