Can I read Cloning and Characterization of a Lambert-eaton Myasthenic Syndrome Antigen on EtoBox?

Cloning and Characterization of a Lambert-eaton Myasthenic Syndrome Antigen by Myrna R. Rosenfeld; Ellen Wong; Josep Dalmau; Geoff Manley; Jerome B. Ponser; Emanuele Sher; Dr. Henry M. Furneaux is a Medicine article available to read on EtoBox.

What is Cloning and Characterization of a Lambert-eaton Myasthenic Syndrome Antigen about?

## Abstract Lambert‐Eaton myasthenic syndrome is a paraneoplastic neuromuscular disorder in which an immune response directed against a small‐cell lung tumor crossreacts with antigens in the neuromuscular junction. To isolate and characterize the antigens, We screened a human fetal brain expression library with a high‐titer serum from a patient with Lambert‐Eaton myasthenic syndrome. This screening resulted in the isolation of a complementary DNA clone encoding an antigen we call myasthenic syndrome antigen B (MysB). Approximately 43% (3 of 7) of Lambert‐Eaton myasthenic syndrome sera specifically recognized MysB fusion protein, whereas none of 34 control sera did. The predicted amino acid sequence of this clone shows a high degree of homology to the b̃ subunit of calcium channel complexes. The MysB pre‐messenger RNA is alternatively spliced to yeild 3 forms of the protein differing in the domain between two highly conserved α‐helical segments.

Who reads Cloning and Characterization of a Lambert-eaton Myasthenic Syndrome Antigen?

Author

Myrna R. Rosenfeld; Ellen Wong; Josep Dalmau; Geoff Manley; Jerome B. Ponser; Emanuele Sher; Dr. Henry M. Furneaux

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0364-5134)

Published

1993

Language

EN

Field

Medicine (Health Sciences)