Can I read Cuprizone-induced Dopaminergic Hyperactivity and Locomotor Deficit in Zebrafish Larvae on EtoBox?
Cuprizone-induced Dopaminergic Hyperactivity and Locomotor Deficit in Zebrafish Larvae by Meng Liu; Peiwen Zheng; Miaomiao Zheng; Weiwei Zhang; Fan Yang; Lan Hong; Xin Yu; Haiyun Xu is a Neuroscience article available to read on EtoBox.
What is Cuprizone-induced Dopaminergic Hyperactivity and Locomotor Deficit in Zebrafish Larvae about?
Cuprizone (CPZ) is a copper-chelator and toxic to mitochondria. Recent studies have shown oligodendrocyte (OL) loss and demyelination along with dopamine (DA) increase and behavioral abnormalities in CPZ-exposed mice, demonstrating its application in schizophrenia research. This study examined effects of CPZ exposure on autonomous behavior and dopaminergic neurotransmission in larval zebra fish. CPZ exposure was found to reduce the swimming velocity of zebra fish thus decreased swimming distance during day and night time. Moreover, the treatment induced a movement response of zebra fish larvae reacting to light-on/off switch featured by swimming velocity increase and decrease during the first and second half of the light-on/off phase, respectively. But, it abolished responses of zebra fish to sound-on/off seen in Control group. HPLC analysis showed elevated DA levels in the zebra fish, no change in NE and 5-HT levels. Transcriptome analysis reported changes in gene expression related to dopaminergic synapse and oxidative phosphorylation in CPZ-exposed larvae relative to Control group. Of the gene expression changes, up-regulation of drd2a, drd2b, drd4a and drd4rs was confirmed by R
Who reads Cuprizone-induced Dopaminergic Hyperactivity and Locomotor Deficit in Zebrafish Larvae?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Meng Liu; Peiwen Zheng; Miaomiao Zheng; Weiwei Zhang; Fan Yang; Lan Hong; Xin Yu; Haiyun Xu
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Neuroscience (Life Sciences)