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Correlation Between Serum Levels of Interleukin-6 and Vascular Endothelial Growth Factor in Gastric Carcinoma by Shih-Pei Huang; Ming-Shiang Wu; Hsiu-Po Wang; Chang-Shiu Yang; Min-Liang Kuo; Jaw-Town Lin is a Medicine article available to read on EtoBox.
What is Correlation Between Serum Levels of Interleukin-6 and Vascular Endothelial Growth Factor in Gastric Carcinoma about?
## Abstract **__Background and Aim:__** Vascular endothelial growth factor (VEGF) and interleukin‐6 (IL‐6) are associated with the disease status of gastric carcinoma. However, their relationship remains unclear. This study aims to determine and correlate serum levels of VEGF and IL‐6 in gastric carcinoma. **__Methods:__** A total of 107 patients receiving gastrectomy entered this study. Serum levels of VEGF and IL‐6 were measured by using ELISA, and were analyzed by using the Student's __t__‐test to compare means and by Pearson correlation analysis to calculate correlation coefficients with respect to pathological characteristics including depth of tumor invasion, Laurén's classification, tumor location, Borrmann classification, and the status of lymph node metastasis. **__Results:__** Serum VEGF levels were significantly higher in patients with mixed type carcinoma (387.5 ± 176.9 __vs__ 255.3 ± 154.1 pg/mL, __P__ = 0.047) or lymph node metastasis (339.1 ± 205.1 __vs__ 223.2 ± 197.4 pg/mL, __P__ = 0.007). Serum IL‐6 levels were significantly higher in patients with Borrmann type IV carcinoma, compared with Borrmann type II and III carcinoma. In general, no correlation was noted be
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- Author
- Shih-Pei Huang; Ming-Shiang Wu; Hsiu-Po Wang; Chang-Shiu Yang; Min-Liang Kuo; Jaw-Town Lin
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0815-9319)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)