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This study investigates the role of the nucleus accumbens (NAc) in stress susceptibility and resilience, focusing on the activity of D1 and D2 medium spiny neurons (MSNs) in mice. Using fiber photometry, researchers found that increased baseline activity in D1-MSNs predicts resilience to stress, while differences in D2-MSN activity are less specific. These findings suggest that pre-existing neuronal activity patterns can identify individuals at risk for stress-induced depression, potentially guiding prevent

Author

maria.teresa.merantee

Language

EN