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Mitotic cycle reactivation in terminally differentiated cells by adenovirus infection: CELL CYCLE REACTIVATION IN POSTMITOTIC CELLS by Marco Crescenzi; Silvia Soddu; Franco Tatò is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Mitotic cycle reactivation in terminally differentiated cells by adenovirus infection: CELL CYCLE REACTIVATION IN POSTMITOTIC CELLS about?

Different cell types (e.g., neurons, skeletal and heart myocytes, adipocytes, keratinocytes) undergo terminal differentiation, in which acquisition of specialized functions entails definitive withdrawal from the cell cycle. Such cells are distinct from quiescent (reversibly growth-arrested) cells, such as contact-inhibited fibroblasts. Terminally differentiated cells can not be induced to proliferate by means of growth factor stimulation or transduction of cellular oncogenes. An important first step toward defining the molecular basis for such unresponsiveness is to find a practical means to overcome the proliferative block. Furthermore, determining whether terminally differentiated, postmitotic cells still retain a potential competence for proliferation that can be reactivated would have important theoretical and practical implications. To address these questions, we exploited the properties of adenoviruses. These viruses can infect postmitotic cells and express E l A, a powerful activator of proliferation in reversibly growth-arrested cells. We infected terminally differentiated skeletal muscle cells and adipocytes with human adenovirus type 5 or 12, obtaining full reentry into t

Who reads Mitotic cycle reactivation in terminally differentiated cells by adenovirus infection: CELL CYCLE REACTIVATION IN POSTMITOTIC CELLS?

Author

Marco Crescenzi; Silvia Soddu; Franco Tatò

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

1995

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)