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Can I read Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice on EtoBox?
Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice by Eugenie Dubnau; John Chan; Catherine Raynaud; Vellore P. Mohan; Marie‐Antoinette Lanéelle; Keming Yu; Annaik Quémard; Issar Smith; Mamadou Daffé is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice about?
Members of the __Mycobacterium tuberculosis__ group synthesize a family of long‐chain fatty acids, mycolic acids, which are located in the cell envelope. These include the non‐oxygenated α‐mycolic acid and the oxygenated keto‐ and methoxymycolic acids. The function in bacterial virulence, if any, of these various types of mycolic acids is unknown. We have constructed a mutant strain of __M. tuberculosis__ with an inactivated __hma__ (__cmaA__, __mma4__) gene; this mutant strain no longer synthesizes oxygenated mycolic acids, has profound alterations in its envelope permeability and is attenuated in mice.
Who reads Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Eugenie Dubnau; John Chan; Catherine Raynaud; Vellore P. Mohan; Marie‐Antoinette Lanéelle; Keming Yu; Annaik Quémard; Issar Smith; Mamadou Daffé
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0950-382X)
- Published
- 2000
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)