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Dapagliflozin Attenuates the Vulnerability to Atrial Fibrillation in Rats with Lipopolysaccharide-induced Myocardial Injury by Xin Zhao; Yating Liu; Xueyu Han; Xiukun Wang; Chuan Qu; Xin Liu; Bo Yang is a Immunology and Microbiology article available to read on EtoBox.

What is Dapagliflozin Attenuates the Vulnerability to Atrial Fibrillation in Rats with Lipopolysaccharide-induced Myocardial Injury about?

Background: Oxidative stress is an essential component participating in the development and maintenance of atrial fibrillation (AF). Dapagliflozin, a SGLT2 inhibitor, has been shown to exert cardioprotective effects by ameliorating oxidative stress in multiple heart disease models. However, its potential to attenuate lipopolysaccharide (LPS)-induced myocardial injury in rats remains unknown. Aim: This study aims to investigate the role of dapagliflozin in LPS-induced myocardial injury and the potential mechanisms involved. Methods: Rats were intraperitoneally administered LPS to induce sepsis-like condition. The intervention was conducted with intraperitoneal injection of dapagliflozin or saline 1 h in advance. The effects of dapagliflozin were detected by electrophysiological recordings, western blot, qPCR, ELISA, HE staining, immunohistochemistry and fluorescence. We further validated the mechanism in vitro using HL-1 cells. Results: Dapagliflozin significantly improved LPS-induced myocardial injury, reduced susceptibility to AF, and mitigated atrial tissue inflammatory cell infiltration and atrial myocyte apoptosis. These were correlated with the Nrf2/HO-1 signaling pathway, whi

Who reads Dapagliflozin Attenuates the Vulnerability to Atrial Fibrillation in Rats with Lipopolysaccharide-induced Myocardial Injury?

Author

Xin Zhao; Yating Liu; Xueyu Han; Xiukun Wang; Chuan Qu; Xin Liu; Bo Yang

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Immunology and Microbiology (Life Sciences)