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TNF-α pathway and T-cell immunity are activated early during the development of diabetic nephropathy in Type II Diabetes Mellitus by Lampropoulou, Ioanna Theologia; Stangou, Îaria; Sarafidis, Pantelis; Gouliovaki, Antigoni; Giamalis, Panagiotis; Tsouchnikas, Ioannis; Didangelos, Triantafillos; Papagianni, Îikaterini is a Immunology and Microbiology article available to read on EtoBox.

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Aim of the present study was to investigate the possible involvement of TNF-α signaling pathway and T-lymphocyte activation in DN. Eighty-two diabetic patients [39 male, age 69.5(56-78)years] were divided into three groups, according to Albumin/Creatinine ratio (ACR) levels, Group I (ACR 300 μg/mg). Urinary Tumor Necrosis Factor-α (TNF-α), and serum TNF-α, ΤNF-receptor 1 (TNFR1), TNFR2, B7-1, CD28, Cytoxic T-Lymphocyte-Associated protein-4 (CTLA4), were estimated. There were significant differences between Groups I, II, III regarding the concentration of urinary TNF-α (p < .001), serum TNFR1 (p < .001), serum TNFR2(p < .001), CTLA4 (p < .001) and CD28(p = .034). In multivariate analysis, independent parameters correlated with ACR were serum TNFR1 (p = .003), TNFR2 (p = .012) and urinary TNF-α (p = .015) levels. There was a significant correlation between markers of T-cell activation and TNF-α signaling pathway activation. Activation of TNF-α signaling pathway and T-lymphocytes seem to synergize and participate in the development of DN in type II DM.

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Author

Lampropoulou, Ioanna Theologia; Stangou, Îaria; Sarafidis, Pantelis; Gouliovaki, Antigoni; Giamalis, Panagiotis; Tsouchnikas, Ioannis; Didangelos, Triantafillos; Papagianni, Îikaterini

Publisher

Elsevier Science; Elsevier ; Elsevier - Academic Press; Elsevier Inc.; Academic Press; Elsevier BV (ISSN 1090-2341)

Published

2020

Language

EN

Field

Immunology and Microbiology (Life Sciences)