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Can I read Modeling Glioblastoma Complexity with Organoids for Personalized Treatments on EtoBox?
Modeling Glioblastoma Complexity with Organoids for Personalized Treatments by Kristen D. Raue; Joseph T. Duffy; Maria V. Babak; Irina V. Balyasnikova is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Modeling Glioblastoma Complexity with Organoids for Personalized Treatments about?
Glioblastoma (GBM) remains a fatal diagnosis despite the current standard of care of maximal surgical resection, radiation, and temozolomide (TMZ) therapy. One aspect that impedes drug development is the lack of an appropriate model representative of the complexity of patient tumors. Brain organoids derived from cell culture techniques provide a robust, easily manipulatable, and high-throughput model for GBM. In this review, we highlight recent progress in developing GBM organoids (GBOs) with a focus on generating the GBM microenvironment (i.e., stem cells, vasculature, and immune cells) recapitulating human disease. Finally, we also discuss the use of organoids as a screening tool in drug development for GBM.
Who reads Modeling Glioblastoma Complexity with Organoids for Personalized Treatments?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Kristen D. Raue; Joseph T. Duffy; Maria V. Babak; Irina V. Balyasnikova
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)
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