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Discordant Responses Between Primary Head and Neck Tumors and Nodal Metastases Treated With Neoadjuvant Nivolumab: Correlation of Radiographic and Pathologic Treatment Effect by Merlino, Dante J.; Johnson, Jennifer M.; Tuluc, Madalina; Gargano, Stacey; Stapp, Robert; Harshyne, Larry; Leiby, Benjamin E.; Flanders, Adam; Zinner, Ralph; Axelrod, Rita; Curry, Joseph; Cognetti, David M.; Mannion, Kyle; Kim, Young J.; Rodeck, Ulrich; Argiris, Athanassios; Luginbuhl, Adam J. is a Medicine article available to read on EtoBox.

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PD-1 blockade represents a promising treatment in patients with head and neck squamous cell carcinoma (HNSCC). We analyzed results of a neoadjuvant randomized window-of-opportunity trial of nivolumab plus/minus tadalafil to investigate whether immunotherapy-mediated treatment effects vary by site of involvement (primary tumor, lymph nodes) and determine how radiographic tumor shrinkage correlates with pathologic treatment effect. ## Patients and Methods Forty-four patients enrolled in trial NCT03238365 were treated with nivolumab 240 mg intravenously on days 1 and 15 with or without oral tadalafil, as determined by random assignment, followed by surgery on day 31. Radiographic volumetric response (RVR) was defined as percent change in tumor volume from pretreatment to posttreatment CT scan. Responders were defined as those with a 10% reduction in the volume of the primary tumor or lymph nodes (LN). Pathologic treatment effect (PTE) was defined as the area showing fibrosis or lymphohistiocytic inflammation divided by total tumor area. ## Results Sixteen of 32 patients (50%) with pathologic evidence of LN involvement exhibited discordant PTE between primary sites and LN. In four pati

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Author

Merlino, Dante J.; Johnson, Jennifer M.; Tuluc, Madalina; Gargano, Stacey; Stapp, Robert; Harshyne, Larry; Leiby, Benjamin E.; Flanders, Adam; Zinner, Ralph; Axelrod, Rita; Curry, Joseph; Cognetti, David M.; Mannion, Kyle; Kim, Young J.; Rodeck, Ulrich; Argiris, Athanassios; Luginbuhl, Adam J.

Publisher

Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2011- (ISSN 2234-943X)

Published

2020

Language

EN

Field

Medicine (Health Sciences)