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American Association of Clinical Endocrinologists and American College of Endocrinology Disease State Clinical Review: A Neuroendocrine Approach to Patients With Traumatic Brain Injury by Nicholas A. Tritos; Kevin C.J. Yuen; Daniel F. Kelly is a Medicine article available to read on EtoBox.

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## Objective: Traumatic brain injury (tbi) is now recognized as a major public health concern in the united states and is associated with substantial morbidity and mortality in both children and adults. several lines of evidence indicate that tbi-induced hypopituitarism is not infrequent in tbi survivors and may contribute to the burden of illness in this population. the goal of this article is to review the published data and propose an approach for the neuroendocrine evaluation and management of these patients. ## Methods: To identify pertinent articles, electronic literature searches were conducted using the following keywords: "traumatic brain injury," "pituitary," "hypopituitarism," "growth hormone deficiency," "hypogonadism," "hypoadrenalism," and "hypothyroidism." relevant articles were identified and considered for inclusion in the present article. ## Results: Tbi-induced hypopituitarism appears to be more common in patients with severe tbi. however, patients with mild tbi or those with repeated, sports-, or blast-related tbi are also at risk for hypopituitarism. deficiencies of growth hormone and gonadotropins appear to be most common and have been associated with increase

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Author

Nicholas A. Tritos; Kevin C.J. Yuen; Daniel F. Kelly

Publisher

American Association of Clinical Endocrinologists; American Association of Clinical Endocrinology; AACE Corp (American Association of Clinical Endocrinologists); Elsevier BV (ISSN 1530-891X)

Published

2015

Language

EN

Field

Medicine (Health Sciences)