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LC‐MS/MS in the elucidation of an isomer of the recreational drug methylenedioxy ethylamphetamine: Methylenedioxy dimethylamphetamine by Sofie R. Vande Casteele; Marie‐Paule L. Bouche; Jan F. Van Bocxlaer is a Chemistry article available to read on EtoBox.
What is LC‐MS/MS in the elucidation of an isomer of the recreational drug methylenedioxy ethylamphetamine: Methylenedioxy dimethylamphetamine about?
## Abstract This paper describes the surplus value of a quadrupole‐orthogonal acceleration TOF mass spectrometer, coupled to a liquid chromatographic separation system, for the unequivocal identification and structural elucidation of an unknown compound in the field of designer drugs. In a patient sample set (blood, tissues, vitreous humor, __etc.__), analyzed with a dedicated liquid chromatographic–fluorescence detection method for the determination of methylenedioxy amphetamine, methylenedioxy methamphetamine, and methylenedioxy ethylamphetamine (MDEA), a “strange” inexplicable peak appeared at a retention time not corresponding to any of our reference materials. Based on the identical excitation and emission wavelengths in detection, and a retention behavior comparable to MDEA, it was assumed that this unknown compound was an isomer of the recreational drug MDEA. With a simple and straightforward methodological crossover between LC fluorescence detection and LC‐MS/MS, additional information for structural elucidation was easily obtained. Chromatographic separation was achieved on a Hypersil BDS C18 column (fluorescence detection part) and on a Hypersil BDS phenyl column (mass sp
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It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Sofie R. Vande Casteele; Marie‐Paule L. Bouche; Jan F. Van Bocxlaer
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1615-9306)
- Published
- 2005
- Language
- EN
- Field
- Chemistry (Physical Sciences)