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Effects of three months' diet after diagnosis of Type 2 diabetes on plasma lipids and lipoproteins (UKPDS 45). UK Prospective Diabetes Study Group by UK Prospective Diabetes Study (UKPDS) Group; S. E. Manley; I. M. Stratton; C. A. Cull; V. Frighi; E. A. Eeley; D. R. Matthews; R. R. Holman; R. C. Turner; H. A. W. Neil is a Medicine article available to read on EtoBox.

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## Aims: To assess the effect of diet on fasting plasma lipids and lipoproteins in patients with newly diagnosed type 2 diabetes. ## Methods: A total of 2,906 patients each underwent 3 months' diet therapy before allocation to therapy in a randomized controlled clinical trial. lipids and lipoproteins were measured at diagnosis and after 3 months' diet. ## Results: The mean body weight at diagnosis was 83 kg. weight decreased after diet by a mean of 4.5 kg; body mass index (bmi) decreased by 1.51 kg/m2; plasma glucose fell by 3 mmol/l from 11 mmol/l; and hba1c by 2% from 9%. triglyceride concentrations were reduced in men by -0.41 (95% confidence interval (ci) -0.47 to - 0.35) mmol/l from a geometric mean 1.8 (1 sd interval 1.0-3.0) mmol/l, and in women by -0.23 (-0.28 to -0.18) mmol/l from a similar level. cholesterol decreased in men by -0.28 (-0.33 to -0.24) mmol/l from 5.5 (1.1) mmol/l, and in women by -0.09 (-0.14 to -0.04) mmol/l from 5.8 (1.2) mmol/l with corresponding changes in ldl cholesterol. hdl cholesterol increased in men by 0.02 (0.01 to 0.04) mmol/l and in women by 0.01 (0 to 0.02) mmol/l. triglyceride concentration in the top tertile was reduced by 37% in men (> 2.1

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Author

UK Prospective Diabetes Study (UKPDS) Group; S. E. Manley; I. M. Stratton; C. A. Cull; V. Frighi; E. A. Eeley; D. R. Matthews; R. R. Holman; R. C. Turner; H. A. W. Neil

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0742-3071)

Published

2000

Language

EN

Field

Medicine (Health Sciences)