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Can I read Immunologic and Histopathologic Characterization of an Active Disease Mouse Model for Pemphigus Vulgaris on EtoBox?
Immunologic and Histopathologic Characterization of an Active Disease Mouse Model for Pemphigus Vulgaris by Manabu Ohyama; Masayuki Amagai; Kazuyuki Tsunoda; Takayuki Ota; Shigeo Koyasu; Jun-ichi Hata; Akihiro Umezawa; Takeji Nishikawa is a Medicine article available to read on EtoBox.
What is Immunologic and Histopathologic Characterization of an Active Disease Mouse Model for Pemphigus Vulgaris about?
Pemphigus vulgaris is an autoimmune blistering disease of the skin and mucous membranes that is caused by anti-desmoglein 3 IgG autoantibodies. Recently, we generated an active disease mouse model for pemphigus vulgaris by adoptive transfer of splenocytes from immunized desmoglein 3-/- mice to Rag2-/- mice. In this study, we performed immunologic and histopathologic studies using this pemphigus vulgaris model in mice and compared the gross and microscopic phenotypes of pemphigus vulgaris model mice and desmoglein 3-/- mice. Pemphigus vulgaris model mice showed strong in vivo IgG, and weak IgA deposition on keratinocyte cell surfaces in stratified squamous epithelia, and produced circulating anti-desmoglein 3 IgG antibodies without apparent cross-reactivity to desmoglein 1, in enzyme-linked immunosorbent assays. The predominant IgG subclass was IgG1. Pemphigus vulgaris model mice and desmoglein 3-/- mice were almost indistinguishable in terms of both gross and microscopic findings. Both types of mice showed suprabasilar acantholysis in the stratified squamous epithelia, including the oral mucous membranes and traumatized skin around the snout or paws; however, some pemphigus vulgari
Who reads Immunologic and Histopathologic Characterization of an Active Disease Mouse Model for Pemphigus Vulgaris?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Manabu Ohyama; Masayuki Amagai; Kazuyuki Tsunoda; Takayuki Ota; Shigeo Koyasu; Jun-ichi Hata; Akihiro Umezawa; Takeji Nishikawa
- Publisher
- Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; Springer Science and Business Media LLC; Wiley (ISSN 0022-202X)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)