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A UPLC-MS/MS method was developed to determine nobiletin and tangeretin in rat plasma, utilizing a liquid-liquid extraction with ethyl acetate. The pharmacokinetics of both compounds were evaluated, revealing bioavailability rates of 63.9% for nobiletin and 46.1% for tangeretin. This study provides a reliable analytical approach for monitoring these flavonoids, which are significant for their biological activities.

Author

dimatkho

Language

EN