Can I read Thermochemotherapy effect of nanosized As2O3/Fe3O4complex on experimental mouse tumors and its influence on the expression of CD44v6, VEGF-C and MMP-9 on EtoBox?

Thermochemotherapy effect of nanosized As2O3/Fe3O4complex on experimental mouse tumors and its influence on the expression of CD44v6, VEGF-C and MMP-9 by Yiqun Du; Dongsheng Zhang; Hui Liu; Rensheng Lai is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Thermochemotherapy effect of nanosized As2O3/Fe3O4complex on experimental mouse tumors and its influence on the expression of CD44v6, VEGF-C and MMP-9 about?

## Abstract ## Background Both thermotherapy and arsenic have been shown to be active against a broad spectrum of cancers. To reduce the limitations of conventional thermotherapy, improve therapeutic anticancer activity, reduce the toxicity of arsenic on normal tissue, and increase tissue-specific delivery, we prepared a nanosized As~2~O~3~/Fe~3~O~4~ complex (Fe~3~O~4~ magnetic nanoparticles encapsulated in As~2~O~3~). We assessed the thermodynamic characteristics of this complex and validated the hyperthermia effect, when combined with magnetic fluid hyperthermia (MFH), on xenograft HeLa cells (human cervical cancer cell line) in nude mice. We also measured the effect on the expression of __CD44v6__, __VEGF-C__, and __MMP-9__ which were related to cancer and/or metastasis. ## Results The nanosized As~2~O~3~/Fe~3~O~4~ particles were approximately spherical, had good dispersibility as evidenced by TEM, and an average diameter of about 50 nm. With different concentrations of the nanosized As~2~O~3~/Fe~3~O~4~ complex, the correspondingsuspension of magnetic particles could attain a steady temperature ranging from 42°C to 65°C when placed in AMF for 40 min. Thermochemotherapy with the

Who reads Thermochemotherapy effect of nanosized As2O3/Fe3O4complex on experimental mouse tumors and its influence on the expression of CD44v6, VEGF-C and MMP-9?

Author

Yiqun Du; Dongsheng Zhang; Hui Liu; Rensheng Lai

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1472-6750)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)