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Heterojunction structured BiOCl-Bi2S3 nanosheets as mitochondria-targeted near-infrared photothermal and photodynamic therapy agent by Shouning Yang; Shengkun Wang; Yanmin Zhang; Yijing Wang; Jinhong Yuan; Yuqin Jiang; Xing He; Lihong Liu; Jian Song; Liang Chen; Huayan Yang is a Materials Science article available to read on EtoBox.

What is Heterojunction structured BiOCl-Bi2S3 nanosheets as mitochondria-targeted near-infrared photothermal and photodynamic therapy agent about?

Mitochondria-targeted phototherapy, especially combined photothermal therapy (PTT) and photodynamic therapy (PDT), has been regarded as an attractive strategy for the treatment of tumor. In this study, a facile approach to prepare two-dimensional (2D) BiOCl-Bi2S3 nanostructures was developed, where Bi2S3 quantum dots were doped in/on the ultrathin BiOCl nanosheets, forming a p-n heterojunction. The BiOCl-Bi2S3 shows favorable photothermal conversion efficiency (32%) and synergistically reactive oxygen species (ROS) generating capability under near-infrared (NIR) irradiation. Moreover, the conjugation of synthetic targeting ligand to the surface of BiOCl-Bi2S3 endows the heterojunction effective tumor targeting ability and selective mitochondrial accumulation. The combined cancer targeting ability and synergistic PTT/PDT permit enhanced cooperative phototherapeutic efficiency of the 2D heterojunction. This study provides an attractive way for designing new class of heterostructure materials for potential applications in subcellular-targeted phototherapy.

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Author

Shouning Yang; Shengkun Wang; Yanmin Zhang; Yijing Wang; Jinhong Yuan; Yuqin Jiang; Xing He; Lihong Liu; Jian Song; Liang Chen; Huayan Yang

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Materials Science (Physical Sciences)