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Can I read Recurrent familial hypobetalipoproteinemia-induced nonalcoholic fatty liver disease after living donor liver transplantation: Recurrent Fatty Liver of the Graft on EtoBox?
Recurrent familial hypobetalipoproteinemia-induced nonalcoholic fatty liver disease after living donor liver transplantation: Recurrent Fatty Liver of the Graft by Noboru Harada; Yuji Soejima; Akinobu Taketomi; Tomoharu Yoshizumi; Hideaki Uchiyama; Toru Ikegami; Toshiharu Saibara; Takashi Nishizaki; Yoshihiko Maehara is a Medicine article available to read on EtoBox.
What is Recurrent familial hypobetalipoproteinemia-induced nonalcoholic fatty liver disease after living donor liver transplantation: Recurrent Fatty Liver of the Graft about?
Familial hypobetalipoproteinemia (FHBL) is one of the causes of nonalcoholic steatohepatitis (NASH) and a codominant disorder. Patients heterozygous for FHBL may be asymptomatic, although they demonstrate low plasma levels of low-density lipoprotein (LDL) cholesterol and apolipoprotein B. Here we report a nonobese 54-year-old man with decompensated liver cirrhosis who underwent living donor liver transplantation with his son as the donor. Low albuminemia and refractory ascites persisted after transplantation. A biopsy specimen obtained 11 months after liver transplantation revealed severe steatosis and fibrosis, and recurrent NASH was diagnosed on the basis of pathological findings. Both the patient's and donor's laboratory tests demonstrated low LDL cholesterol and apolipoprotein levels. Because mutations in messenger RNAs of microsomal triglyceride transfer protein and apolipoprotein B genes were excluded neither in the recipient nor in the donor, both were clinically diagnosed as being heterozygous for FHBL. We successfully treated the recipient with heterozygous FHBL-induced recurrent NASH after liver transplantation using our diet and exercise programs.
Who reads Recurrent familial hypobetalipoproteinemia-induced nonalcoholic fatty liver disease after living donor liver transplantation: Recurrent Fatty Liver of the Graft?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Noboru Harada; Yuji Soejima; Akinobu Taketomi; Tomoharu Yoshizumi; Hideaki Uchiyama; Toru Ikegami; Toshiharu Saibara; Takashi Nishizaki; Yoshihiko Maehara
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)