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Construction of an STK11 Mutation and Immune-Related Prognostic Prediction Model in Lung Adenocarcinoma by Bo Tang; Xia Zhao; Hongbing Liu; Qingfeng Zhang; Kui Liu; Xiaoyan Yang; Yun Huang is a scholarly article available to read on EtoBox.

What is Construction of an STK11 Mutation and Immune-Related Prognostic Prediction Model in Lung Adenocarcinoma about?

## Background: __STK11__ mutation in LUAD affects immune cell infiltration in tumor tissue, and is associated with tumor prognosis. ## Objective: This study aimed to construct a __STK11__ mutation and immune-related LUAD prognostic model. ## Materials and Methods: The mutation frequency of __STK11__ in LUAD was queried via cBioPortal in TCGA and PanCancer Atlas databases. The degree of immune infiltration was analyzed by CIBERSORT analysis. DEGs in __STK11__mut and __STK11__wt samples were analyzed. Metascape, GO and KEGG methods were adopted for functional and signaling pathway enrichment analysis of DEGs. Genes related to immune were overlapped with DEGs to acquire immune-related DEGs, whose Cox regression and LASSO analyses were employed to construct prognostic model. Univariate and multivariate Cox regression analyses verified the independence of riskscore and clinical features. A nomogram was established to predict the OS of patients. Additionally, TIMER was introduced to analyze relationship between infiltration abundance of 6 immune cells and expression of feature genes in LUAD. ## Results: The mutation frequency of __STK11__ in LUAD was 16%, and the degrees of immune cell i

Author

Bo Tang; Xia Zhao; Hongbing Liu; Qingfeng Zhang; Kui Liu; Xiaoyan Yang; Yun Huang

Published

2023