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Comparison of Apparent Diffusion Coefficients and Distributed Diffusion Coefficients in High-grade Gliomas by Thomas C. Kwee; Craig J. Galbán; Christina Tsien; Larry Junck; Pia C. Sundgren; Marko K. Ivancevic; Timothy D. Johnson; Charles R. Meyer; Alnawaz Rehemtulla; Brian D. Ross; Thomas L. Chenevert is a Medicine article available to read on EtoBox.
What is Comparison of Apparent Diffusion Coefficients and Distributed Diffusion Coefficients in High-grade Gliomas about?
## Abstract ## Purpose: To compare apparent diffusion coefficients (ADCs) with distributed diffusion coefficients (DDCs) in high‐grade gliomas. ## Materials and Methods: Twenty patients with high‐grade gliomas prospectively underwent diffusion‐weighted MRI. Traditional ADC maps were created using b‐values of 0 and 1000 s/mm^2^. In addition, DDC maps were created by applying the stretched‐exponential model using b‐values of 0, 1000, 2000, and 4000 s/mm^2^. Whole‐tumor ADCs and DDCs (in 10^−3^ mm^2^/s) were measured and analyzed with a paired t‐test, Pearson's correlation coefficient, and the Bland‐Altman method. ## Results: Tumor ADCs (1.14 ± 0.26) were significantly lower (__P__ = 0.0001) than DDCs (1.64 ± 0.71). Tumor ADCs and DDCs were strongly correlated (__R__ = 0.9716; __P__ < 0.0001), but mean bias ± limits of agreement between tumor ADCs and DDCs was −0.50 ± 0.90. There was a clear trend toward greater discordance between ADC and DDC at high ADC values. ## Conclusion: Under the assumption that the stretched‐exponential model provides a more accurate estimate of the average diffusion rate than the mono‐exponential model, our results suggest that for a little diffusion attenua
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- Author
- Thomas C. Kwee; Craig J. Galbán; Christina Tsien; Larry Junck; Pia C. Sundgren; Marko K. Ivancevic; Timothy D. Johnson; Charles R. Meyer; Alnawaz Rehemtulla; Brian D. Ross; Thomas L. Chenevert
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)