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Can I read Concentration-dependence of Biomarkers of Exposure of Methylenediphenyl-diisocyanate Following Acute Inhalation Exposure of Rats on EtoBox?
Concentration-dependence of Biomarkers of Exposure of Methylenediphenyl-diisocyanate Following Acute Inhalation Exposure of Rats by Jürgen Pauluhn; Gabriele Leng is a Environmental Science article available to read on EtoBox.
What is Concentration-dependence of Biomarkers of Exposure of Methylenediphenyl-diisocyanate Following Acute Inhalation Exposure of Rats about?
Rats were nose-only exposed for 6 h to polymeric methylenediphenyl-diisocyanate (pMDI). Concentrations varied from 0.12 to 12.7 mg/m(3) using a highly respirable aerosol. In regard to the concentration of the monomeric fraction of MDI contained in pMDI, the lowest concentration was in the range of the current workplace limit of MDI which is 0.05 mg/m(3). Biomarkers of exposure were determined in hydrolyzed urine (collection started after cessation of exposure for approximately 18 h; acid hydrolysis) and hydrolyzed hemoglobin (collection of blood approximately 20 h after cessation of exposure; alkaline hydrolysis). The determination revealed two-order of magnitudes higher yields of the biomarkers in urine when compared to hemoglobin. The concentration of analytes from the respective biological matrix was highly correlated with the airborne concentration of pMDI whilst their yields exhibited a reciprocal relationship to the airborne concentration of pMDI. A linear relationship could only be demonstrated by using a logarithmic transformation of data. With respect to the amount of 4,4'-methylenediphenyldianiline creatinine (MDA/g creatinine) in hydrolyzed urine of rats at an exposure l
Who reads Concentration-dependence of Biomarkers of Exposure of Methylenediphenyl-diisocyanate Following Acute Inhalation Exposure of Rats?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Jürgen Pauluhn; Gabriele Leng
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)
- Published
- 2003
- Language
- EN
- Field
- Environmental Science (Life Sciences)