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Three new HLA-G alleles and their linkage disequilibria with HLA-A by Pablo Morales; Alfredo Corell; Jorge Martínez-Laso; J. Manuel Martín-Villa; Pilar Varela; Estela Paz-Artal; Luis-M. Allende; Antonio Arnaiz-Villena is a Immunology and Microbiology article available to read on EtoBox.

What is Three new HLA-G alleles and their linkage disequilibria with HLA-A about?

Three new allelic forms of the HLA-G DNA sequence (HLA-G\*II, HLA-G\*III, and HLA-G\*IV) have been identified. With the HLA-G\*I sequence (previously designated HLA 6.0) as a reference, HLA-G\*II shows a silent (G-->A) mutation at the third base of codon 57, HLA-G\*III bears a non-synonymous (A-->T), but conservative, (Thr-->Ser) substitution at the first base of codon 31, and HLA-G\*IV shows two silent substitutions: (A-->T) at the third base of codon 107 and (G-->A) at the third base of codon 57. A rapid method of singling out each allele on genomic DNA has been developed by using polymerase chain reaction amplification followed by restriction endonuclease treatment. Also, more or less strong linkage disequilibria has been found between most HLA-A alleles and either HLA-G\*I or \*II, both being the most prevalent alleles in the population, with a genotypic frequency of 0.55 and 0.38, respectively; HLA-G\*III is very rare and HLA-G\*IV has a genotypic frequency of 0.07. An evolutive classification of HLA-A alleles results according to their association with either HLA-G\*I or HLA-G\*II, which does not correlate with the classical serological cross-reacting groups classification. T

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Author

Pablo Morales; Alfredo Corell; Jorge Martínez-Laso; J. Manuel Martín-Villa; Pilar Varela; Estela Paz-Artal; Luis-M. Allende; Antonio Arnaiz-Villena

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0093-7711)

Published

1993

Language

EN

Field

Immunology and Microbiology (Life Sciences)