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Zinc Oxide Nanoparticles Reduce the Chemoresistance of Gastric Cancer by Inhibiting Autophagy by You-Han Miao; Li-Ping Mao; Xiao-Juan Cai; Xiao-Ying Mo; Qi-Qi Zhu; Fei-Tong Yang; Mei-Hua Wang is a Medicine article available to read on EtoBox.

What is Zinc Oxide Nanoparticles Reduce the Chemoresistance of Gastric Cancer by Inhibiting Autophagy about?

## BACKGROUND Gastric cancer (GC) is a common malignancy that results in a high rate of cancer-related mortality. Cisplatin (DDP)-based chemotherapy is the first-line clinical treatment for GC therapy, but chemotherapy resistance remains a severe clinical challenge. Zinc oxide nanoparticle (ZnO-NP) has been identified as a promising anti-cancer agent, but the function of ZnO-NP in GC development is still unclear. ## AIM To explore the effect of ZnO-NP on chemotherapy resistance during GC progression. ## METHODS ZnO-NP was synthesized, and the effect and underlying mechanisms of ZnO-NP on the malignant progression and chemotherapy resistance of GC cells were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays, colony formation assays, transwell assays, wound healing assays, flow cytometry, and Western blot analysis in GC cells and DDP-resistant GC cells, and by tumorigenicity analyses in nude mice. ## RESULTS Our data revealed that ZnO-NP was able to inhibit proliferation, migration, and invasion and induce apoptosis of GC cells. Meanwhile, ZnO-NP significantly reduced the half maximal inhibitory concentration (IC~50~) of DDP for the inhibition of c

Who reads Zinc Oxide Nanoparticles Reduce the Chemoresistance of Gastric Cancer by Inhibiting Autophagy?

Author

You-Han Miao; Li-Ping Mao; Xiao-Juan Cai; Xiao-Ying Mo; Qi-Qi Zhu; Fei-Tong Yang; Mei-Hua Wang

Publisher

Baishideng Publishing Group Inc.

Published

2021

Language

EN

Field

Medicine (Health Sciences)